Monitoring Osseointegration: The Role of Bone Biomarkers in Dental Implant Success
Abstract
Dental implant success hinges on the biological processes of bone remodeling and osseointegration, with bone biomarkers now recognized as powerful adjuncts to conventional clinical and radiographic assessments. Recent prospective and systematic studies indicate that dynamic biomarker monitoring can inform predictions of implant prognosis, illuminate the mechanisms of peri-implant bone turnover, and enable the early diagnosis of complications, such as peri-implantitis. Advances in omics technologies and molecular imaging have expanded our understanding, while new candidate biomarkers have emerged from peri-implant crevicular fluid, blood, and metabolomic profiles. This review critically synthesizes the major developments between 2000 and 2025 and evaluates the clinical utility, challenges, and future direction of bone biomarker analysis in modern implant dentistry.
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